abstract：:There are hundreds of foods, nutrients, herbs, and botanicals that have "bioactive" constituents with potential human health benefits. Three of these are discussed in this review: soy, garlic, and ginkgo biloba. Each of these three choices involves an ingestible item composed of a complex mixture of bioactive agents. ...

journal_title：Current atherosclerosis reports

authors： Gardner CD,Messina M,Lawson LD,Farquhar JW

更新日期：2003-11-01 00:00:00

abstract：:Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or acquired disorders. However, the majority of coagulation disorde...

journal_title：Current atherosclerosis reports

authors： Bushnell C,Goldstein LB

更新日期：2003-07-01 00:00:00

abstract：:Atherosclerosis remains the major cause of morbidity and mortality in Western countries. Atherothrombotic complications, including vascular occlusions and severe narrowing of nutrient blood vessels in the cerebral, coronary, or peripheral circulation, usually require invasive revascularization strategies. As molecular...

journal_title：Current atherosclerosis reports

authors： Janssens SP

更新日期：2003-05-01 00:00:00

abstract：:A wide range of structurally unrelated antioxidants inhibit atherosclerosis in animal models of hypercholesterolemia, implicating oxidation of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, most prospective, randomized trials of one proposed antioxidant, vitamin E, have failed to demons...

journal_title：Current atherosclerosis reports

authors： Heinecke JW

更新日期：2003-03-01 00:00:00

abstract：:Plant-derived alpha-linolenic acid has been studied in a limited number of investigations. So far, some epidemiologic and a few mechanistic studies suggest a potential of protection from cardiovascular disease, but this potential remains to be proven in intervention studies. In contrast, eicosapentaenoic acid (EPA) an...

journal_title：Current atherosclerosis reports

authors： von Schacky C

更新日期：2003-03-01 00:00:00

abstract：:The ability of statins to lower serum cholesterol and reduce coronary heart disease endpoints has confirmed portions of the lipid hypothesis. However, the time to benefit and increased benefit in overlapping populations have suggested that nonlipid or pleiotropic effects of statins may be present. The apparent benefit...

journal_title：Current atherosclerosis reports

authors： Callahan AS 3rd

更新日期：2003-01-01 00:00:00

abstract：:The Third Report of the National Cholesterol Education Program's Adult Treatment Panel (ATP III) has an extensive section on nonpharmacologic therapy for those with abnormal blood lipids. ATP III focused on the high-saturated fat atherogenic diet, obesity, and sedentary lifestyle and recommended a program of therapeut...

journal_title：Current atherosclerosis reports

authors： Stone NJ,Van Horn L

更新日期：2002-11-01 00:00:00

abstract：:Erectile dysfunction (ED) is a common problem in the United States, with estimates that 30 million men suffer with some degree of ED. Although causes include psychogenic, organic, and mixed forms, in middle-aged and older men one of the most common causes is vascular disease. Endothelial dysfunction, even without defi...

journal_title：Current atherosclerosis reports

authors： Kloner RA,Speakman M

更新日期：2002-09-01 00:00:00

abstract：:Augmentative and alternative communication (AAC) strategies traditionally have been designed for individuals for whom oral speech is not a viable option. Common clinical practice has expanded AAC use to a tool for cognitive retraining or remediation. Although technologic developments offer the potential for vastly imp...

journal_title：Current atherosclerosis reports

authors： Ansel BM,Weinrich M

更新日期：2002-07-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAA) are permanent dilations in the infra-renal area in which the arterial tissue is characterized by inflammation and medial degeneration. AAAs are a common vascular disorder and cause significant mortality in the aged population. Despite the high prevalence of this disease, there is limit...

journal_title：Current atherosclerosis reports

authors： Daugherty A,Cassis LA

更新日期：2002-05-01 00:00:00

abstract：:Recent randomized trials of hormone replacement therapy (HRT) in postmenopausal women are not consistent with the decrease in cardiovascular risk seen in observational studies of hormone therapy users compared with nonusers. Emerging evidence indicates that HRT use in some women with established coronary heart disease...

journal_title：Current atherosclerosis reports

authors： Duvernoy CS,Mosca L

更新日期：2002-03-01 00:00:00

abstract：:Few principles in medicine today are as well accepted as the benefits of using statins to reduce cardiovascular risk factors and to prevent cardiovascular disease. The recent withdrawal of a statin (cerivastatin) has lead to a re-examination of all statins, and an attempt to better assess the risk-benefit ratio of thi...

journal_title：Current atherosclerosis reports

authors： Black DM

更新日期：2002-01-01 00:00:00

abstract：:We have developed, tested, and successfully implemented an affordable, evidence-based, comprehensive cardiovascular disease risk-reduction program for use in primary and secondary prevention settings. The program is administered at hospitals, physician practices, cardiac rehabilitation programs, work sites, shopping m...

journal_title：Current atherosclerosis reports

authors： Gordon NF,Salmon RD,Mitchell BS,Faircloth GC,Levinrad LI,Salmon S,Saxon WE,Reid KS

更新日期：2001-11-01 00:00:00

abstract：:Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconcepti...

journal_title：Current atherosclerosis reports

authors： Parthasarathy S,Khan-Merchant N,Penumetcha M,Khan BV,Santanam N

更新日期：2001-09-01 00:00:00

abstract：:Several studies confirm cognitive impairment and dementia to be increased after stroke in the elderly. Although not necessarily involving memory deficits, the frequency of cognitive impairments may occur in up to 30% of stroke survivors at 3 months. This impairment may be confounded by preexisting cognitive decline or...

journal_title：Current atherosclerosis reports

authors： Kalaria RN,Ballard C

更新日期：2001-07-01 00:00:00

abstract：:Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a n...

journal_title：Current atherosclerosis reports

authors： Talmud PJ

更新日期：2001-05-01 00:00:00

abstract：:This review concerns the clinical impact of low-density lipoprotein (LDL) apheresis for patients with refractory hypercholesterolemia. We examine and provide examples of investigations that have demonstrated the clinical benefits of LDL apheresis. In addition to benefits derived from the stabilization or regression of...

journal_title：Current atherosclerosis reports

authors： Moriarty PM,Gibson CA

更新日期：2001-03-01 00:00:00

abstract：:Olive oil is the principal source of fat in the Mediterranean diet, which has been associated with a lower incidence of coronary heart disease and certain cancers. Olive oil is characterized by a high proportion of monounsaturated oleic acid, but the main peculiarity of extra-virgin oil is the presence of remarkable q...

journal_title：Current atherosclerosis reports

authors： Visioli F,Galli C

更新日期：2001-01-01 00:00:00

abstract：:Functional foods are foods that, by virtue of physiologically active food components, provide health benefits beyond basic nutrition. Many functional foods have been found to be potentially beneficial in the prevention and treatment of cardiovascular disease, the leading cause of mortality in the United States. These ...

journal_title：Current atherosclerosis reports

authors： Hasler CM,Kundrat S,Wool D

更新日期：2000-11-01 00:00:00

abstract：:Plant foods rich in carbohydrate and dietary fiber have many health benefits. One concern often expressed about higher carbohydrate, lower fat diets is that they may increase fasting serum triglycerides. Recently the importance of hypertriglyceridemia as an independent risk factor for coronary heart disease has been r...

journal_title：Current atherosclerosis reports

authors： Anderson JW

更新日期：2000-11-01 00:00:00

abstract：:Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystroph...

journal_title：Current atherosclerosis reports

authors： Reue K,Péterfy M

更新日期：2000-09-01 00:00:00

abstract：:More than half of the men and women in the United States are overweight or obese. Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD). The location of excessive body fat, particularly in the visceral area, has ...

journal_title：Current atherosclerosis reports

authors： Jones PH

更新日期：2000-07-01 00:00:00

abstract：:Recent studies confirm and extend previous evidence that lipoprotein (Lp) plays a significant role in atherosclerosis and is one of the top five or six risk factors for cardiovascular disease. In Japanese patients, Lp levels and apo phenotypes are significant predictors for myocardial infarction. Lp levels are signifi...

journal_title：Current atherosclerosis reports

authors： Morrisett JD

更新日期：2000-05-01 00:00:00

abstract：:Serum cholesterol traditionally has been considered a poor predictor of total stroke risk; however, it is associated positively with ischemic stroke risk and associated negatively with hemorrhagic stroke risk. Although studies failed to demonstrate stroke reduction using older cholesterol-lowering medications, recent ...

journal_title：Current atherosclerosis reports

authors： Ansell BJ

更新日期：2000-03-01 00:00:00

abstract：:Various lifestyle factors have been associated with increasing the risk of stroke. These include lack of exercise, alcohol, diet, obesity, smoking, drug use, and stress. Guidelines endorsed by the Centers for Disease Control and Prevention and the National Institutes of Health recommend that Americans should exercise ...

journal_title：Current atherosclerosis reports

authors： Boden-Albala B,Sacco RL

更新日期：2000-03-01 00:00:00

abstract：:The cytochrome P450 (CYP) is a group of enzymes that oxidatively modify drugs to a more water-soluble form for renal excretion. Nearly 50% of all clinically used medications and endogenous steroids are metabolized by the CYP enzyme 3A4, which explains why many of the important potential drug interactions involved this...

journal_title：Current atherosclerosis reports

authors： Davidson MH

更新日期：2000-01-01 00:00:00

abstract：:There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindivid...

journal_title：Current atherosclerosis reports

authors： Ordovas JM,Galluzzi JR

更新日期：1999-11-01 00:00:00

abstract：:With ever increasing sophistication in molecular biological approaches, the low-density lipoprotein receptor supergene family continues to grow rapidly. From the well-defined key role of these receptors in lipoprotein metabolism, the new members move the field into many different and diverse physiologic and developmen...

journal_title：Current atherosclerosis reports

authors： Schneider WJ,Nimpf J,Brandes C,Drexler M

更新日期：1999-09-01 00:00:00

abstract：:Atherosclerotic cardiovascular diseases are the most common causes of death in the United States. Fibrous plaques develop in 77% to 78% of men before age 30. The mean low-density lipoprotein-cholesterol (LDL-C) level in men aged 25 to 30 years is 117 mg/dL. In the Air Force/Texas Coronary Atherosclerosis Prevention St...

journal_title：Current atherosclerosis reports

authors： Whitney E

更新日期：1999-07-01 00:00:00